Brian Anderson, MD, MsC

Brian Anderson, MD, MsC

Brian Anderson, MD, MSc, is a psychiatrist and researcher in the department of psychiatry at University of California, San Francisco, where he is a co-investigator on a clinical trial of psilocybin-assisted psychotherapy for long-term AIDS survivors.
Brian Anderson, MD, MsC

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Bia Labate, Ph.D.

Bia Labate, Ph.D.

Bia Labate has a Ph.D in anthropology. She has published 19 books about psychedelic plant medicines, shamanism, religion, ritual and drug policy. She is an Executive Director at Chacruna.
Bia Labate, Ph.D.

Matthew Meyer, Ph.D

Matthew Meyer, Ph.D

Matthew Meyer was born in Northern California and grew up in Chico. He was a Rotary exchange student to Brazil after high school, and later did fieldwork in the Brazilian Amazon for his PhD in anthropology (U Virginia 2014).
Matthew Meyer, Ph.D

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    Kenneth Tupper, Ph.D

    Kenneth Tupper, Ph.D

    Kenneth Tupper, Ph.D., is the Director of Implementation & Partnerships at BC Centre on Substance Use and also an Adjunct Professor in the School of Population and Public Health at the University of British Columbia.
    Kenneth Tupper, Ph.D

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      Paulo C R Barbosa, Ph.D.

      Paulo C R Barbosa, Ph.D.

      Paulo C R Barbosa, Ph.D., is Professor the Universidade Estadual de Santa Cruz (UESC). Over the last 20 years he has conducted psychological and neuropsychological assessments of ayahuasca users, and has participated in preclinical studies evaluating the effects of ayahuasca on abuse of drugs.
      Paulo C R Barbosa, Ph.D.

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        Charles Grob, M.D.

        Charles Grob, M.D.

        Charles Grob, M.D. is Professor of Psychiatry and Pediatrics at the UCLA School of Medicine.Over the last thirty years he has conducted approved research with MDMA, psilocybin and ayahuasca.
        Charles Grob, M.D.

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          Andrew Dawson, Ph.D.

          Andrew Dawson, Ph.D.

          Andrew Dawson, Ph.D., is Professor of Modern Religion in the Department of Politics, Philosophy and Religion at Lancaster University, UK. He obtained his doctorate at Oxford University and has degrees in social science and religious studies.
          Andrew Dawson, Ph.D.

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            Dennis McKenna, Ph.D

            Dennis McKenna, Ph.D

            Dennis McKenna, Ph.D, has studied the botany, chemistry and pharmacology of ayahuasca since 1981, when he first traveled to Peru as a graduate student at the University of British Columbia.
            Dennis McKenna, Ph.D

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              Editorial Note: This statement is a few years old so the status of some “current” issues mentioned may have changed. Yet, its basic concerns and information are more relevant than ever given recent arrests and developments.

              Sixty years ago, the esteemed academic journal Science published a “Statement on Peyote” (La Barre, McAllester, Slotkin, Stewart, & Tax, 1951), in which a handful of leading researchers, dismayed by the misinformed and demonising drug politics of the time, defended the right of the Native American Church to consume a psychedelic plant in its religious rites. Today, we feel similarly compelled to speak out on behalf of an analogous, non- indigenous religious tradition—the Brazilian ayahuasca religions, including the Santo Daime, the União do Vegetal, and other related groups (Dawson, 2007; Labate & MacRae, 2010). We have studied various ritual uses of ayahuasca, participated in ceremonies and consumed the sacramental brew.

              As the Brazilian ayahuasca religions have spread from South America to North America, Europe and Asia over the past few decades, their members have suffered arrests, criminal prosecu- tion, and stigmatization as “drug users.” Currently, Santo Daime members in the UK, Ireland, Spain, and Portugal are facing criminal charges, and the protection of religious freedom for Santo Daime members in Canada remains tentative and unresolved (Tupper, 2011). Meanwhile, in the US, Oregon-based Santo Daime mem- bers are in negotiations with the Department of Justice (Church v. Holder, 2012), and in a highly politicized case, the União do Veg- etal was recently denied a permit for building a temple in New Mexico (Haywood, 2011). We contend that such barriers to the freedom of religious practice are both legally and ethically unten- able; moreover, as with oppression of the Native American Church (Calabrese, 2004; Halpern, Sherwood, Hudson, Yurgelun-Todd, & Pope, 2005), intolerance of the Brazilian ayahuasca religions is not based on rational risk/benefit evaluations of consequences, either for individual practitioners or for public safety. Instead, persecution of the Brazilian ayahuasca religions has been mostly based on misinformed prejudice against the use of psychedelic substances in what are reasonably safe and socially controlled rit- ual contexts, and which constitute authentic cultural traditions and expressions that must be respected as such. Here we discuss the scientific evidence available on these practices, and we argue that the data justify modelling future regulation of these religions on Brazil’s largely self-enforced policies, which treat ayahuasca more like a religious sacrament than a controlled psychotropic substance (Labate & Feeney, 2012). Such policies have proven successful in Brazil over the past several decades and they have allowed the Brazilian ayahuasca religions to develop the intriguing social, health and research implications that they present us with today.

              Ayahuasca is a psychedelic decoction made from plants native to the Amazon Basin—most often Banisteriopsis caapi and Psychotria viridis—and which contains harmala alkaloids and N,N- dimethyltryptamine (DMT), the latter being a controlled substance scheduled under the 1971 Convention on Psychotropic Substances (UN, 1971). Substantial English-language academic literature on ayahuasca, especially on its uses in the Brazilian ayahuasca reli- gions, has only been available for the last two decades (Labate, Rose, & Santos, 2009). The belief systems of the different religions bring together Christian, Spiritist, African and Indigenous traditions with influences from contemporary urban spiritualities. There is no standard ritual performed by all the Brazilian ayahuasca religions, but there are some commonalities across the groups: rituals are usually held every 2 weeks and often commence in the evening; church members wear clothing reflective of the historical and cul- tural contexts in which the different groups were founded; after initial prayers are said, the religious leaders give each congregant a small glass of ayahuasca in a ritualized manner that evokes the distribution of wine in other Christian settings; finally, the ritu- als are designed to slightly outlast the psychoactive effects of the ayahuasca (about 4 h). These effects can include the sensation of an intimate proximity to God or other spiritual beings; a general inten- sification of emotions, particularly those of a positive valence (e.g., tranquillity and reverence); a tendency toward introspection; sen- sations of enhanced lucidity and comprehension; and sensations of enhanced perceptual acuity accompanied by an increased vividness of closed-eye visualizations. Somatic effects can include sensations of bodily heaviness or lightness, nausea, vomiting, and diarrhoea (it is important to note that, for the practitioners of these religions, vomiting is associated with bodily and spiritual cleansing).

              Over the decades, the Brazilian ayahuasca religions have devel- oped their rituals and theological teachings to incorporate the strong psychological effects of ayahuasca within systems of belief and practice that are immensely rich with spiritual meaning for worshipers, and significantly distinct from the problematic uses of drugs like alcohol, tobacco, and the opiates (i.e., use associated with dependence, debilitating illness or social harms). Unfor- tunately, however, recent media depictions of these Brazilian religions have sensationalized ayahuasca, mistakenly portrayed   it as a dangerous street drug, and even erroneously confused it with pure DMT and compared its harms to those of metham- phetamine (Rommelman & Mesh, 2011; The Sun, 2010; UK Border Agency, 2010). Contrary to these descriptions of ayahuasca and its effects, the few biomedical studies of the physical and men- tal health of members of the Brazilian ayahuasca religions have shown no harm from consuming the brew in these contexts. Find- ings from case–control and cross-sectional studies of long-term members include the following: ayahuasca’s acute physiological and subjective effects are relatively benign, and adults with over a decade’s worth of regular ayahuasca use in the União do Vegetal retain normal neurocognitive functioning (Callaway et al., 1999; Grob et al., 1996); there is a relative absence of psychopathol- ogy in adult members of the Santo Daime (Halpern, Sherwood, Passie, Blackwell, & Ruttenber, 2008); adolescents who have con- sumed ayahuasca in the União do Vegetal at least monthly for 2 years show normal psychiatric and neuropsychological profiles, an absence of excessive drug use, and normal development of moral decision-making (da Silveira et al., 2005; Dobkin de Rios et al., 2005; Doering-Silveira, Grob, et al., 2005; Doering-Silveira, Lopez, et al., 2005); and no signs of deleterious medical and social consequences were found in long-term Santo Daime and Bar- quinha members (Fábregas et al., 2010). Moreover, a prospective study of new ayahuasca users showed improvements in measures of mental health and physical pain 6 months after beginning to attend Santo Daime and União do Vegetal ceremonies, respec- tively (Barbosa, Cazorla, Giglio, & Strassman, 2009). These data are corroborated and contextualized by a plethora of ethnographic studies that attest to the healthy and functional nature of these communities, which have now regularly consumed ayahuasca for several generations (Brissac, 2010; MacRae, 1992; Mercante, 2010).

              Toxicology studies in animals have found that the chemical constituents of ayahuasca could be harmful, but at dosages and patterns of ingestion of questionable relevance to those seen in the Brazilian ayahuasca religions (Pires, Oliveira, & Yonamine, 2010). Meanwhile, lyophilized ayahuasca has been shown to be safe to administer to humans in laboratory settings (Riba et al., 2001), as has pure DMT (Strassman, 1996); and the acute effects of lyophilized ayahuasca on human immune function appear to be equivocal (Santos et al., 2011). Ayahuasca has been used exper- imentally to induce a model psychosis in humans (Pinto, 2010), although it is unlikely that ayahuasca and other psychedelics can cause psychotic illness sui generis; rather, it is suggested that they may occasionally precipitate psychotic episodes in persons with a predisposition to such states (Jones, 2009; Strassman, 1984). This hypothesis is supported by preliminary data (collected and ana- lyzed by physicians who are themselves members of the União do Vegetal) that suggest that the incidence of psychosis among União do Vegetal members compares to that of the Brazilian population in general (Assis & Tófoli, 2011). No deaths have been confirmed to be directly attributable to ayahuasca use (Gable, 2007).

              Aside from indicating a general lack of harm from  the  reli- gious use of ayahuasca, biomedical and ethnographic studies have also generated preliminary evidence in support of the therapeutic potentials of ayahuasca or its constituents for alleviating substance dependence (Grob et al., 1996; Labate, Santos, Anderson, Mercante, & Barbosa,  2010)  and  mood  and  anxiety  disorders  (Fortunato et al., 2010; Santos, Landeira-Fernandez, Strassman, Motta, & Cruz, 2007). The study of ayahuasca could thus contribute to advances  in ethnopharmacology and the cognitive sciences (Shanon, 2002), yet such studies are severely compromised when these traditions face the threat of legal sanction. And for those readers who doubt that contemporary ethnopharmacological drug research conducted with a religious group that uses psychedelic plants could come to fruition and produce an officially accepted medical therapy, they only need look to the fact that the US federal government, through the Indian Health Service, recognizes the administration of Native American Church peyote ceremonies as an effective and reim- bursable treatment for substance dependence (Calabrese,     2004).

              The Native American Church was roughly 80 years old when La Barre et al. published their “Statement on Peyote,” denouncing a prejudiced and misleading political campaign to outlaw this minor- ity religious tradition. With the legal protection granted to it, not only for medical but also for cultural and historical reasons, the Native American Church has evolved over the decades into a stable, multigenerational religious tradition practiced throughout North America and which provides its members deeply meaningful and beneficial spiritual experiences through the ritualized consump- tion of a powerful psychedelic plant (Stewart, 1987).

              Today the form of  ritual  ayahuasca  use  that  has  come  to be known as the Brazilian ayahuasca religions is also about 80 years old. In Brazil, the ayahuasca religions have been largely self-regulated as a result of federal government investigations, beginning in the 1980s, which have repeatedly found these reli- gions to be beneficial contributors to the communities in which they are established (Labate & Feeney, 2012; National Council for Drug Policy, 2010). In Brazil, these religions are not merely per- mitted to practice, but increasingly they are being recognized as cultural heritage, as in the 2006 declaration of certain buildings of the Centro de Iluminac¸ ão Cristã Luz Universal (the oldest Brazilian ayahuasca religion) as part of the “historical patrimony” of Brazil’s Acre state. Similarly, in 2008, the traditional knowledge and use of ayahuasca by native Amazonian communities were deemed part of Peruvian national heritage (Labate & Goldstein, 2009). The Brazil- ian ayahuasca religions currently practice their faiths with varying degrees of government permission or tolerance in Canada, the Netherlands, Spain, and several other countries around the world (Labate & Jungaberle, 2011), not to mention the United States where the União do Vegetal won their case before the US Supreme Court in 2006 and the Santo Daime won their district court case in Oregon in 2009; both churches were subsequently issued federal licences to import and to consume ayahuasca in their rituals (Labate, 2012). This expansion has been aided by the fact that the UN International Narcotics Control Board considers ayahuasca not to be controlled under either the 1971 or the 1988 UN Conventions on psychotropic substances (Tupper & Labate, in press; UNINCB, 2011).

              In light of these facts—that ritualized psychedelic plant use has expanded out of the Amazon in recent decades; that the available data consistently suggest that these practices are reasonably safe; and that, nevertheless, considerations of medical and public safety must be balanced with socio-historical and human rights consid- erations, such as the universal right to freedom of religion—we urge regulatory authorities in the countries where the Brazilian ayahuasca religions are currently arriving to demonstrate tolerance and grant these groups the necessary degree of legal freedom and respectful engagement for them to continue evolving into safe and responsible contributors to today’s multicultural and globalizing society.

              References

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              Barbosa, P. C. R., Cazorla, I. M., Giglio, J. S., & Strassman, R. (2009). A six-month prospective evaluation  of  personality  traits,  psychiatric  symptoms  and  qual-  ity of life in ayahuasca-naive subjects. Journal of Psychoactive Drugs, 41(3), 205–212.

              Brissac, S. (2010). In the light of Hoasca:  An  approach  to  the  religious  expe-  rience of participants of  the  União  do  Vegetal.  In  B.  C.  Labate,  &  E. MacRae (Eds.), Ayahuasca, ritual and religion in Brazil (pp. 135–160). London: Equinox.

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              Dawson, A. (2007). New era New religions: Religious transformation in contemporary Brazil. Ashgate: Aldershot.

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              Grob, C. S., McKenna, D. J., Callaway, J. C., Brito, G. S., Neves, E. S., Oberlaender, G., et al. (1996). Human psychopharmacology of Hoasca: A plant hallucinogen used  in ritual context in Brazil. The Journal of Nervous and Mental Disease, 184(2), 86–94.

              Halpern, J. H., Sherwood, A. R., Hudson, J. I., Yurgelun-Todd, D., & Pope, H. G., Jr. (2005). Psychological and cognitive effects of long-term peyote use among Native Amer- icans. Biological Psychiatry, 58, 624–631.

              Halpern,   J.   H.,   Sherwood,   A.   R.,   Passie,   T.,   Blackwell,   K.   C.,   &   Ruttenber, A. J. (2008). Evidence of health and safety  in  American  members  of  a  reli- gion who use a hallucinogenic sacrament. Medical Science Monitor, 14(8), SR15–SR22.

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              Labate, B. C., & Feeney, K. (2012). Ayahuasca and the process of regulation in Brazil and internationally: Implications and challenges. International Journal of Drug Policy, 23(2), 154–161.

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              Tupper, K. W. (2011). Ayahuasca, entheogenic education and public policy (Doctoral dissertation). University of British   Columbia.

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              UK Border  Agency.  (2010).  UK  Border  Agency  seizes  hallucinogenic  drug  sent  in post. Retrieved from: http://webarchive.nationalarchives.gov.uk/20111208172642/http://www.ukba.homeoffice.gov.uk/sitecontent/newsarticles/2010/oct/22-ukba-seizes-drugs-via-posthttp://www.ukba.homeoffice.gov.uk/sitecontent/newsarticles/2010/oct/22-ukba-seizes-drugs-via-post United Nations. (1971). Convention on psychotropic substances. United Nations. Retrieved from: http://www.incb.org/pdf/e/conv/convention 1971 en.pdf United Nations International Narcotics Control Board. (2011). Report of the International  Narcotics  Control  Board  for  2010.   UN   Publication   sales No. E.11.XI.1. Retrieved from: http://www.incb.org/pdf/annual-report/2010/ en/AR 2010 English.pdf

              ——

              Note: 

              This text was originally published in 2012 in the International Journal of Psychoactive Drugs.
              Republished with permission of the Journal.