North America is currently in the grips of a public health crisis rooted in the use of licit and illicit opioid-based analgesics. Drug overdose...

Simon Ruffell, et.al. provide a systematic review of the pharmacological interaction of chemical compounds in ayahuasca. The researchers wanted to better understand which chemicals in ayahuasca are required to achieve positive outcomes, questions remain regarding which components are essential, how they interact, and what happens if they are removed.

The labeling of the psychedelic experience as ‘mystical’ may do little to improve public opinion about psychedelics, especially among those with traditional, conservative values. While it is no surprise that psychedelics can induce deep spiritual experiences, there is no scientific evidence that psychedelics can change one’s political or religious beliefs.

How can the use of psychedelic and sacred plants help alleviate human suffering? What are the barriers to such “plant medicines,” like ayahuasca, becoming...

Anya Ermakova provides an overview of the psychoactive mushrooms found in Mexico & the cultural & conservation issues associated with them.

The ayahuasca world can promise big things: curing illness, healing trauma, and personal contact with spirits and divine beings. But what can you really expect,...

The growth of quantitative ayahuasca research has failed to account for the essential impact of context on study participants. To address this issue, T.J. Wolfe and S. Ruffell, et.al. employed a heuristic study to further explore the phenomenology of the ayahuasca experience in a traditional setting.

This article summarizes psychiatric and neuroscientific findings on the similarities between psychedelic and psychiatric hallucinations.

Ibogaine is a potent psychedelic substance found mainly in the root bark of the shrub Tabernanthe iboga, native of the Congo and Gabon, as...

This excerpt from the book Fly Agaric: A Compendium of History, Pharmacology, Mythology, & Exploration explores the wonderous amanita muscaria mushroom. While many people have considered this mushroom to be dangerous to human health, this essay explores the medicinal therapeutic benefits that may come from consuming it. Kevin Feeney explains its history and analyzes studies that have been conducted surrounding the human consumption of this fungus.