This excerpt from the book Fly Agaric: A Compendium of History, Pharmacology, Mythology, & Exploration explores the wonderous amanita muscaria mushroom. While many people have considered this mushroom to be dangerous to human health, this essay explores the medicinal therapeutic benefits that may come from consuming it. Kevin Feeney explains its history and analyzes studies that have been conducted surrounding the human consumption of this fungus.

The first report that ibogaine could reduce opioid withdrawal symptoms and opioid craving dates back to the early 1960s. Since then, there has been...

Ibogaine is a potent psychedelic substance found mainly in the root bark of the shrub Tabernanthe iboga, native of the Congo and Gabon, as...

The growth of quantitative ayahuasca research has failed to account for the essential impact of context on study participants. To address this issue, T.J. Wolfe and S. Ruffell, et.al. employed a heuristic study to further explore the phenomenology of the ayahuasca experience in a traditional setting.

When someone is diagnosed with a severe, life-threatening illness, the affected individual may begin to ask several existential questions. The author, Lucas Maia, PhD, summarizes his findings from his doctoral thesis which studied the ritual use of ayahuasca and its therapeutic potential for those facing and fearing death.

Kelan Thomas writes about a new psilocybin group therapy clinical trial for demoralized AIDS survivors that was recently published by Chacruna board member Dr. Brian Anderson.

As a Brazilian ayahuasca scholar, I am frequently asked about the number of ayahuasca drinkers in my country. This is a tricky question, since...

Dr.’s Aryan Sarparast, Chris Stauffer, Kelan Thomas, and Benjamin Malcolm, recently published the first systematic review of drug interactions between psychiatric medications and psychedelics: “Drug-drug interactions between psychiatric medications and MDMA or psilocybin: A systematic review.” In this article, the authors offer a synopsis of their systematic review.

This article summarizes psychiatric and neuroscientific findings on the similarities between psychedelic and psychiatric hallucinations.

The rise in popularity of peyote has unfortunately led to overharvesting which consequently poses a great risk for the future of the species. With the increasing need to protect peyote, synthetic mescaline may offer an alternative gateway into this experience that is bereft of issues regarding sustainability. This article summarizes the chemical composition and production of synthetic mescaline.